![]() These studies are all on patients who are candidates for intubation in the operating room, and no study has been performed on emergency patients.ĭue to the lack of studies on emergency patients in this domain and the small number of studies in this field in general, a study was designed to compare the effect of fentanyl and remifentanil on the QTc interval in patients undergoing RSI. Both fentanyl and remifentanil are widely used in RSI, but a few studies have compared the effects of these agents on the QT interval. These drugs can reduce sympathetic tone, and this reduction has a protective role against dysrhythmias caused by QT elongation ( 8). ![]() Drugs such as fentanyl or remifentanil can be used to improve this problem. One of the above mechanisms is the increase of sympathetic tone, which during laryngoscopy also increases the probability of prolongation of QT interval with increasing sympathetic stimulation ( 7). Various mechanisms have been mentioned to prolong this interval. Increasing the length of the modified QT interval, which indicates the potential for ventricular dysrhythmias, may be associated with developing dangerous ventricular dysrhythmias, torsade du point at the top ( 6). One of these complications is the possibility of cardiac dysrhythmia. In this method, medication is used to reduce the complications of gluten stimulation during laryngoscopy. RSI is the standard method of airway control in emergency patients ( 5). The rapid sequence intubation (RSI) method is the cornerstone of modern airway management and includes the preparation of equipment and drugs, supplemental oxygenation, induction, muscle paralysis with a muscle relaxant, endotracheal placement, and postintubation supportive therapies ( 4). These changes are well tolerated in patients without cardiac problems, but in patients with cardiovascular problems and high blood pressure, especially uncontrolled, they can cause many complications (including ischemia) and cardiac dysrhythmias ( 2, 3). Laryngoscopy and endotracheal intubation can increase heart rate and blood pressure, irregular heartbeat, catecholamines, myocardial oxygen demand, myocardial ischemia, and increased intracerebral pressure in susceptible individuals ( 1). ![]() QT Interval Rapid Sequence Intubation Laryngoscopy Fentanyl Remifentanil 1. Therefore, fentanyl and remifentanil during endotracheal intubation did not have a statistically and clinically significant effect on the QT distance of patients' ECG, and the administration of the above two drugs during intubation was safe. In the present study, in comparing the QT interval, there was a statistically significant difference between the two groups receiving fentanyl and remifentanil at any of the studied times.
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